Introduction 

DIABEX is a medication containing the active ingredient metformin hydrochloride, belonging to the class of drugs known as biguanides. It is primarily used to manage blood glucose levels in individuals with type 2 diabetes mellitus. By enhancing the body's response to insulin and reducing glucose production in the liver, DIABEX helps maintain optimal blood sugar levels. 

How does it work? 

● It inhibits gluconeogenesis, thereby reducing the amount of glucose released into the 
bloodstream. 
● Enhances peripheral glucose uptake and utilization. 
● Slows down the absorption of sugar from the intestines into the bloodstream. 

These combined actions help in effectively lowering blood sugar levels without causing 
significant hypoglycemia when used alone. 

How to use it? 

● In type 2 diabetes patients especially in overweight individuals where diet and 
exercise alone have not been sufficient to control blood glucose levels. 
● It is sometimes prescribed to manage insulin resistance associated with PCOS. 

How much to use? 

● Starting Dose: Typically, 500 mg once or twice daily. 
● Maintenance Dose: Depending on blood glucose levels, the dose may be adjusted. 
The maximum recommended daily dose is 2000 mg, divided into multiple doses. 
It's advisable to take DIABEX with meals to minimize gastrointestinal side effects. Always 
follow your healthcare provider's instructions regarding dosage and administration.

Potential side effects 

● Common Side Effects: 

         ○ Nausea 
         ○ Vomiting 
         ○ Diarrhea 
         ○ Abdominal discomfort 
         ○ Loss of appetite 

● Serious Side Effects (Seek immediate medical attention if you experience): 

        ○ Symptoms of lactic acidosis: Trouble breathing, feeling weak or tired, unusual 
             muscle pain, dizziness, feeling cold, or slow heartbeat.

For a comprehensive list of side effects, refer to the Consumer Medicine Information (CMI) leaflet provided with the medication.

Precautions and warnings 

Before starting DIABEX, inform your doctor if you have: 

● Kidney or liver problems 
● Heart conditions 
● A history of lactic acidosis 
● Excessive alcohol consumption

NOTE : DIABEX is not recommended during pregnancy or breastfeeding. Discuss with your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding. 

Please note : Certain medications may interact with DIABEX, affecting its efficacy or 
increasing the risk of adverse effects. Inform your doctor if you are taking 

● Diuretics 
● Corticosteroids 
● Blood pressure medications 
● Other antidiabetic drugs 

Always provide a complete list of your current medications to your healthcare provider to ensure safe use. 

Lifestyle recommendations 

      ● Focus on a balanced diet rich in whole grains, vegetables, lean proteins, and                     healthy fats. Limit sugary foods and beverages. 
      ● Engage in at least 150 minutes of moderate-intensity aerobic activity per week,              such as brisk walking or cycling. 
      ● Limit alcohol intake, as it can affect blood sugar control and increase the risk of              lactic acidosis.

Monitoring and follow-up 

Regular monitoring of blood glucose levels is essential to assess the effectiveness of 
DIABEX. Schedule routine follow-up appointments with your healthcare provider to:

     ● Evaluate blood sugar control 
     ● Monitor kidney function 
     ● Adjust medication dosage if necessary 

How to manage missed doses or an overdose? 

    ● Missed Dose: If you miss a dose of DIABEX, take it as soon as you remember, 
       unless it's almost time for your next dose. Do not double up to make up for the 
       missed dose. 
   ● Overdose: In case of an overdose, seek immediate medical attention. Symptoms 
      may include lactic acidosis, which is a medical emergency.

Storage and Handling 

Store DIABEX tablets in a cool, dry place below 25°C, away from direct sunlight and 
moisture. Keep the medication out of reach of children and do not use it beyond the 
expiration date

Frequently asked questions 

1. Can DIABEX cause weight loss? 

Yes, DIABEX has been associated with modest weight loss in some individuals, particularly those who are overweight or obese. 

2. Is DIABEX suitable for type 1 diabetes? 

No, DIABEX is not indicated for type 1 diabetes mellitus. It is specifically used for managing type 2 diabetes. 

3. Can I consume alcohol while taking DIABEX? 

It's advisable to limit alcohol consumption, as it can interfere with blood sugar control and increase the risk of lactic acidosis. 

4. How long does it take for DIABEX to work? 

The onset of action varies among individuals. Some may notice improvements in blood 
sugar levels within a few days, while for others, it may take a couple of weeks. 

5. Can DIABEX be taken during pregnancy? 

DIABEX is not recommended during pregnancy. Consult your healthcare provider for 
alternative treatment options if you are pregnant or planning to become pregnant.

Conclusion 

DIABEX (metformin hydrochloride) is a well-established medication for managing type 2 
diabetes mellitus. When combined with a healthy lifestyle, it effectively helps control blood glucose levels and reduces the risk of diabetes-related complications.