Introduction 

DIABEX is the medication that is having active ingredient metformin hydrochloride in it, and it comes under the group of drugs known as biguanides. It's a drug for stabilizing blood glucose levels in type 2 diabetes. DIABEX keeps the blood sugar levels healthy by increasing the body's sensitivity to insulin as well as lowering the amount of glucose produced in the liver by.

How does it work? 

●  Inhibits gluconeogenesis in the result reducing the quantity of glucose pour into the bloodstream.
● Increases peripheral glucose uptake and utilization.
● Inhibits the absorption of sugar from intestinal surfaces into the bloodstream. 

The complementary activities result in effective lowering of blood sugar levels without resorting to very significant hypoglycemia when used alone. 

How to use it? 

● Particularly indicated in type 2 diabetes patients who are overweight and where diet and exercise alone have proved inadequate in controlling blood glucose levels.
● It is to some extent used to treat insulin resistance in PCOS. 

How much to use? 

● Initiating Dose: Usually, 500 mg once or twice daily. 
● Maintenance Dose: The dose can be adjusted based on the level of blood glucose. The maximum recommended daily dose is 2000 mg, divided into multiple doses. It is preferred to take DIABEX along with meals so as to minimize the intestinal side effects. Always follow the guidance of your doctor concerning dosage and administration.

Potential side effects 

● Common Side Effects: 

         ○ Nausea
        ○ Vomiting
        ○ Diarrhea
        ○ Abdominal discomfort
        ○ Loss of appetite 

● Serious Side Effects (Seek immediate medical attention if you experience): 

        ○ Lactic acidosis symptoms include: difficulty breathing; extreme weakness or fatigue; unusual muscle pain; dizziness; feeling very cold; or minor heartbeat. 

For a complete list of side effects, consult the Consumer Medicine Information leaflet that accompanies your medicine.

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Precautions and warnings 

Before starting treatment with DIABEX, inform your physician if you have: 

● Any kidney or liver problem 
● Heart conditions 
● Previously had episodes of lactic acidosis
● High alcohol consumption

NOTE: The use of DIABEX is not recommended for pregnant women or breastfeeding mothers. If you are pregnant, planning to become pregnant, or are breastfeeding, please have a careful discussion with your healthcare provider. 

NOTE: Some medicines can interfere with the effect of DIABEX or increase the chance of side effects. Inform your doctor if you are taking 

● Diuretics,
● Corticosteroids,
● Medicines for high blood pressure,
● Other antidiabetics. 

Please make sure that you inform your healthcare provider of all your medications for safety.  

Lifestyle recommendations 

      ● Concentrate on a healthy diet that includes whole grains, vegetables, lean protein, and healthy fats. Made available: a small amount of sugary foods and drinks. 
      ● Get involved in moderate-aerobic physical activity for 150 minutes a week; brisk walking and cycling are included. 
      ● Limiting alcohol consumption is recommended as it may interfere with blood sugar control and raise the risk of lactic acidosis.

Monitoring and follow-up 

The evaluation of the therapeutic effectiveness of DIABEX needs regular blood sugar level monitoring. Make sure to arrange follow-up appointments for: 

     ● Evaluating blood sugar control
    ● Monitoring renal function 
    ●Adjusting the dose of medication if necessary 

How to manage missed doses or an overdose? 

    ● Missed Dose: In case you missed taking DIABEX, do take the tablet as soon as you remember about it unless it is the time to take your next prescribed dose; never double your dose.
  ● Overdose: Any case of overdose requires emergency medical care. Symptoms may include lactic acidosis, which is a medical emergency.

Storage and Handling 

DIABEX tablets should be stored in a cool, dry location, below 25 degrees Celcius, and protected from direct sunlight and moisture. Ensure that the medication is kept out of reach of children and is not used after the expiration date. 

Frequently asked questions 

1. Can DIABEX cause weight loss? 

Yes, DIABEX has been associated with modest weight loss in some individuals, particularly those who are overweight or obese. 

2. Is DIABEX suitable for type 1 diabetes? 

No, DIABEX is not indicated for type 1 diabetes mellitus. It is specifically used for managing type 2 diabetes. 

3. Can I consume alcohol while taking DIABEX? 

It's advisable to limit alcohol consumption, as it can interfere with blood sugar control and increase the risk of lactic acidosis. 

4. How long does it take for DIABEX to work? 

The onset of action varies among individuals. Some may notice improvements in blood
sugar levels within a few days, while for others, it may take a couple of weeks. 

5. Can DIABEX be taken during pregnancy? 

DIABEX is not recommended during pregnancy. Consult your healthcare provider for
alternative treatment options if you are pregnant or planning to become pregnant.

Conclusion 

DIABEX, in particular, metformin hydrochloride, is a well-established drug in the management of type 2 diabetes mellitus. Proper use of this drug, in combination with a healthy lifestyle, goes a long way toward controlling blood glucose levels and preventing complications related to diabetes.